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Univ of Nev School of Medicine, Family Medicine Certain allergy and sinus medications are considered safe during pregnancy These include Benadryl (diphenhydramine) and ChlorTrimeton (chlorpheniramine) Sudafed can sometimes be used after the first trimester with the approval of your doctor Show More · A combination of antibiotics, antihistamines, and decongestants is used to fight chronic sinusitis, although many of these medications may not be safe if you are pregnant According to Robyn HorsagerBoehrer, MD at The University of Texas Southwestern Medical Center, "pregnant women should avoid taking unnecessary drugs during pregnancy"Sinusitis is caused by too much mucus, or a swelling of the lining of the sinuses and nose, which can block the narrow channels This can occur during a cold, or may be due to allergy (for example, hayfever) or irritation of the linings of the sinuses (for example, from chlorine in a swimming pool) Allergy And Sinus Relief Reactine Sinus medication ...